AN UNBIASED VIEW OF FRACTAL STORM (SELF-LAID

While in the LSD-bound crystal framework, the facet chain from the lid residue L209EL2 forms substantial hydrophobic contacts with both LSD and surrounding residues in TMs III, IV, and V (Determine 4C). If the lid moved apart to reveal the binding pocket in simulation, quite a few of those contacts broke. We thus hypothesized that L209EL2 functions